In contrast, it has been reported that inhibition of oligodendrocyte apoptosis delayed disease progression and prolonged survival of SOD1 mutant mice (Kang et al., 2013) raising the possibility that inhibition of oligodendrocyte apoptosis is effective for ALS pathology, despite the low number of apoptotic oligodendrocytes even in pathogenic condition. Here, SOD1 is linked to amyotrophic lateral sclerosis.