GLS and central nervous system cancer: The overproduction of 2- hydroxyglutarate (2-HG) in IDH mutant gliomas potently inhibits BACT1/2, which explains why the glutaminase inhibitors specifically sensitized IDH mutant gliomas to oxidation stress compared to IDH wild-type gliomas and suggest the strategy on the basis of redox to obtain maximum effectiveness for gliomas should take into consideration of comprehensive GSH biosynthesis pathways (McBrayer et al., 2018).