The overproduction of 2- hydroxyglutarate (2-HG) in IDH mutant gliomas potently inhibits BACT1/2, which explains why the glutaminase inhibitors specifically sensitized IDH mutant gliomas to oxidation stress compared to IDH wild-type gliomas and suggest the strategy on the basis of redox to obtain maximum effectiveness for gliomas should take into consideration of comprehensive GSH biosynthesis pathways (McBrayer et al., 2018). This evidence concerns the gene GLS and glioma.