On the other hand, RNA-seq data revealed that a variety of immune deficiency markers, such as CD274 (PD-L1), CTLA4, NRP1, and LAGLS9, were increasingly expressed in the high-risk group, which was in line with our previous findings as regards immune suppression of cluster 1 determined by ROGs (Figures 8D, E and Supplementary Figure 8G). This evidence concerns the gene NRP1 and Immunodeficiency.