HSPB1 and myocardial ischemia: Inhibition of electrogenic sodium bicarbonate co-transporter isoform 1 (NBCe1) can increase HSP27 phosphorylation while attenuating Drp1-dependent mitochondrial fission by attenuating calcium overload and activating the calcium-regulated neurophosphatase/p38 MAPK/HSP27-dependent pathway, which can improve mitochondrial status and cardiac function after myocardial ischemia (115).