The cardiorenal protective mechanisms of SGLT2 inhibitors are thought to be complex, including diuretic effects that less activate the renin-angiotensin-aldosterone system with little change in intravascular volume (14, 15), suppression of sympathetic hyperactivity (16), antioxidant effects (17, 18), correction of impaired energy metabolism (19, 20), anti-inflammatory effects (21), improvement of anemia via increased erythropoietin production (22), improved iron metabolism (23), preventing fibrotic changes (24, 25), and preventing effects for the development of cardiorenal syndromes (26). The gene discussed is SLC5A2; the disease is anemia (phenotype).