The covariates in the multivariate models contained demographic factors (age, sex, current smoking), traditional CV risk factors [body mass index (BMI), dialysis, diabetes mellitus, and hypertension], previous cardiovascular disease history (CAD, HFrEF, CVA, CLTI, and atrial fibrillation), actual laboratory results [white blood cell count, neutrophil-lymphocyte ratio, C-reactive protein (CRP), and serum albumin], and medication (antiplatelet agents, β-blockade, renin-angiotensin-aldosterone system inhibitors, and statins). The gene discussed is CRP; the disease is diabetes mellitus.