While the early spread of tau pathology may be associated with minor but detectable changes in verbal memory function reported in aging and prodromal Alzheimer’s disease populations, tau spread in PET-Braak Stages III–IV and beyond may contribute to the striking drop in verbal memory performance observed in clinical and some preclinical Alzheimer’s disease patients.33 This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.