Therefore, our study showed that abnormal expression of SPP1, CLDN8, COL4A6, RND3, DPT, EFS, TNC, AOC3, and TGFB1I1 during the development of PCa could mediate abnormal changes in the adhesion properties of PCa tissues, thus promoting the metastasis and invasion of tumor cells. Here, SPP1 is linked to posterior cortical atrophy.