It was found that the downregulation of MYLK, MYL9, MYH11, CALD1, ACTA2, and CNN1, and the upregulated expression of SPP1, were correlated with significantly worse overall survival in PCa patients, while FLNA, TAGLN, LDB3, TPM1, FLNC, LMOD1, SMTN, and CAV1 expression was not associated with survival (P > 0.05). The gene discussed is SPP1; the disease is posterior cortical atrophy.