TSC2 and neoplasm: The ERBB family includes epidermal growth factor receptor (EGFR) (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4), which are stimulated by ligands to form homodimers or heterodimers to activate intracellular pathways that are part of the RAS/RAF/MEK/ERK and PI3K/AKT/TSC2/mTOR pathways, promoting proliferation and metastasis of tumor cells (63).