In this study, a LASSO Cox risk model and a prognostic nomogram were developed based on the five DEGs upregulated in gemcitabine-resistant PC cells as opposed to gemcitabine-sensitive PC cells, including EGFR, MSLN, ERAP2, ALDH3B1, and NCEH1 (also known as KIAA1363 or AADACL1). The gene discussed is ERAP2; the disease is pachyonychia congenita.