First, RT-qPCR analyses demonstrated that the expression levels of ALDH3B1 and NCEH1 were relatively higher in the three PC cell lines (AsPC-1, CFPAC-1, and PANC-1) than in the normal pancreatic epithelial cell line (hTERT-HPNE) (Figures 11A, B). The gene discussed is ALDH3B1; the disease is pachyonychia congenita.