CD274 and pachyonychia congenita: Mutated KRAS contributes to the development of the immunosuppressive TME in PC through several avenues, including recruitment of MDSCs and Treg cells (80, 81), maintenance of the fibroinflammatory stroma (82), induction of Th17 cells (83), and upregulation of PD-L1 expression via mRNA stabilization (84).