Another unpublished study by the authors shows that CSCs can both directly and indirectly inhibit B cell function through the PD-L1/PD-1 axis on both B cells and Th cells, and anti-PD-L1 could paralyze the suppression of BCSCs on the IgG production secreted by 4T1 tumor reactive B cells. The gene discussed is CD274; the disease is neoplasm.