Moreover, one ongoing study by the authors has indicated that mouse tumor-draining lymph node T cells armed with anti-mCD3/anti-m HER2 bi-specific antibody may selectively target HER2-positive BCSCs and, thus, prevent metastasis in a mouse 4T1 xenograft that does not have HER2 gene amplification, but they have failed to inhibit the HER2-negative primary tumor. The gene discussed is ERBB2; the disease is neoplasm.