Patients with germline DDX41 germline variant have been shown to have higher rates of both severe (stage 3-4) acute graft-versus-host disease (GVHD) (38%) and moderate to severe chronic GVHD (33%) compared to those without any identified P/LP germline variant (9% and 10%, respectively) (36). This evidence concerns the gene DDX41 and graft versus host disease.