GATA2 and myelodysplastic syndrome: As mentioned above, GATA2 deficiency, stemming from pathogenic variants in GATA2, is comprised of a syndrome characterized by life-threatening opportunistic infections with non-tuberculous mycobacteria (NTM), fungal infections, or human papillomavirus (HPV) infections and a propensity to progress to MDS, CMML, and AML (17–19).