As CHF progresses, inflammatory cytokine burst grows, lnc-NOS2P3 expression increases and downregulates miR-939-5p, and target gene iNOS activation and high levels of TNFα and NO production induce massive myocardial injury and ERS apoptosis, at which point the heart enters NYHA III-IV decompensation. Here, NOS2P3 is linked to congestive heart failure.