INS and infection: However, our results indicate an association between the Imd and insulin signaling in D. melanogaster larval anti-nematode response through changes in the transcript levels of Drosophila insulin-like peptides 2 (Dilp2) and (Dilp3). These results provide important insight into the interactions between host immunity and metabolism for fighting infections with parasitic nematodes and thus may lead to the identification of new strategies for treating infectious diseases.