In addition, although subjective symptoms are not relevant for defining anaphylaxis, our study demonstrated that unspecified pruritus, rhinoconjunctivitis, or diarrhea were frequently present in anaphylactic events, demonstrating that, when persistent and evaluated together, these complaints can represent an IgE-mediated allergic reaction29 and be accounted as serious reactions. This evidence concerns the gene IGHE and anaphylaxis.