IL6 and delirium: Noah et al. (2021) found that higher preoperative IL-6 was associated with postoperative delirium. Another meta-analysis performed among surgical patients also found this association (Liu et al., 2018; Adamis et al., 2021). Dunne et al. (2021) showed that early manifestation of systemic inflammation with elevated levels of IL-6 leads to the onset of delirium. However, Hall et al. (2018) did not find a significant correlation between IL-6 measured in CSF and delirium.