Carotenemia develops in hypothyroidism due to deficient conversion of carotene into vitamin A. Thyroid hormone is an antagonist of vitamin A and is also helps mediate the rate of catabolism and conversion from carotene to vitamin A. Therefore, in patients with hypothyroidism and insufficient thyroid hormone the process of conversion of carotene to vitamin A is slowed and may lead to an accumulation and pigmentation of the skin (135). The gene discussed is TG; the disease is hypothyroidism.