Patient baseline PSA ≧̸10 ng/ml (p = 0.000), multiple organ metastasis (p = 0.007), hypertension (p = 0.004), coronary heart disease (p = 0.004), and radiotherapy (p = 0.028) impacted the PFS at univariate analysis of overall cohort. The gene discussed is KLK3; the disease is Hypertension.