Henceforth, recent researches have been focusing on deciphering the underlying mechanism leading to the disease progression from DM to complication with DPN: In a study by Dewanjee et al., the implication of different molecular ad signaling pathways, oxidative stress, interleukins, nerve growth factor, and autophagy was thoroughly assessed in the investigation of the pathogenesis and progression of diabetic neuropathy (24). The gene discussed is NGF; the disease is diabetic neuropathy.