HIF1A and diabetes mellitus: From 2012 till now, there have been only few studies that have highlighted the role of ferroptosis in the development of DPN: For instance, in a study by Feng et al., it was revealed that ferroptosis along the HIF-1α/HO-1 pathway lead to renal tubular injury and fibrosis in DM mice, partly also due to the increased production of ROS and accumulation of lipid peroxidation (13).