From 2012 till now, there have been only few studies that have highlighted the role of ferroptosis in the development of DPN: For instance, in a study by Feng et al., it was revealed that ferroptosis along the HIF-1α/HO-1 pathway lead to renal tubular injury and fibrosis in DM mice, partly also due to the increased production of ROS and accumulation of lipid peroxidation (13). The gene discussed is HMOX1; the disease is diabetes mellitus.