Diet intervention that induce ketogenesis and lipolysis, either through fat-favorable composition of energy sources, or through fasting and caloric intake reduction, have beneficial disease-modifying effects on different neurological disorders including epilepsy (12), multiple sclerosis (13) and central spine injury in humans (14) and in animal models (15) mediated through alterations in extracellular signal-regulated kinases (ERK)- and mammalian target of rapamycin (mTOR)-signaling (16) and in opioid-receptor expression (17). Here, MTOR is linked to epilepsy.