In a multicentre study from Finland and Sweden of 492 women (298 with PCOS and 194 healthy controls), serum levels of the bone formation markers procollagen type 1 N propeptide (P1NP) and osteocalcin were 19% and 13% lower in the PCOS group, respectively, even after adjustment for age and BMI (128). The gene discussed is BGLAP; the disease is polycystic ovary syndrome.