Higher levels of Interleukin IL-1β, IL-2, and granulocyte-macrophage colony-stimulating factor (GM-CSF) at baseline, an early increase in serum thyroglobulin and thyroid autoantibodies, and an early decrease of IL-8, G-CSF, and MCP-1 were found in the ICI-induced thyroid disease group (70). This evidence concerns the gene TG and thyroiditis.