Although it is well documented that IL-1β, IL-6, TNF-α, IL-8, and TGF-β and macrophage inflammatory protein-1a (MIP-1a) are upregulated in AD patients (Domingues et al., 2017), it is not yet fully clarified their role in the onset or progression of AD. The gene discussed is TGFB1; the disease is Alzheimer disease.