TXNIP is over expressed in the brain of AD patients and in several AD mice models and recent data suggest that it participates in AD pathophysiology (Melone et al., 2018; Nasoohi et al., 2018a,b; Wang et al., 2019; Tsubaki et al., 2020; Perrone and Valente, 2021; Zhang M. et al., 2021). The gene discussed is TXNIP; the disease is Alzheimer disease.