TREM2 and Alzheimer disease: Both heterozygous and homozygous Knock out (KO) of TREM2 in these AD models strongly reduce the presence of macrophages associated to Aβ plaques, reducing Aβ plaques load in 4 months old AD mice, while Aβ load is increased in 8 months old AD mice lacking TREM2 (Basha et al., 2023).