In a rat model of AD, obtained by intracerebral injection of streptozotocin (STZ), NLRC4 expression is increased as well as IL-1β production, while the expression of NLRP1, NLRP3, and AIM2 is unvaried compared to control rats, suggesting that NLRC4 promotes inflammation in this AD rat model (Saadi et al., 2020). Here, AIM2 is linked to Alzheimer disease.