Studies in AD and tau mice models suggest that TREM2 plays a dual role in Aβ and tau pathology, appearing to being beneficial in the initial phase of the disease by contributing in altered protein phagocytosis, whereas it exerts a pathological role in the later phase of the disease by enhancing inflammation and neurodegeneration (Kinney et al., 2018). The gene discussed is TREM2; the disease is Alzheimer disease.