Silencing of TXNIP or blockade of RAGE reduces Aβ transport from the cellular surface to mitochondria in microglia, restores mitochondrial functionality, mitigates Aβ toxicity, inhibits NLRP3-induced inflammation and blocks pyroptosis in vivo AD mice and in vitro primary microglia (Sbai et al., 2022). Here, NLRP3 is linked to Alzheimer disease.