IL1B and Alzheimer disease: Peripheral blood mononuclear cells (PBMCs) derived from AD and amnestic mild cognitive impairment (aMCI) patients shows elevated levels of NLRP3, IL-1β and caspase 1, showing the presence of systemic NLRP3 activation and inflammation in aMCI and AD patients (Rui et al., 2021; Figure 1).