Moreover, a study carried out in an in vitro AD model revealed an enhanced expression of genes involved in mitochondrial fission (such as Drp1 and Fis1) and a decreased expression of those related to mitochondrial fusion (such as Mfn1 and Mfn2), altering the mitochondria dynamics and affecting the synaptic function (see below). This evidence concerns the gene DNM1L and Alzheimer disease.