Moreover, a study carried out in an in vitro AD model revealed an enhanced expression of genes involved in mitochondrial fission (such as Drp1 and Fis1) and a decreased expression of those related to mitochondrial fusion (such as Mfn1 and Mfn2), altering the mitochondria dynamics and affecting the synaptic function (see below). The gene discussed is MFN2; the disease is Alzheimer disease.