NLRP3 and Alzheimer disease: In a rat model of AD, obtained by intracerebral injection of streptozotocin (STZ), NLRC4 expression is increased as well as IL-1β production, while the expression of NLRP1, NLRP3, and AIM2 is unvaried compared to control rats, suggesting that NLRC4 promotes inflammation in this AD rat model (Saadi et al., 2020).