Since VGLUT2 is the only VGLUT produced by STN glutamatergic projections to SNpr, we speculate that during STN-HFS, information transmission through the trans-thalamic pathway has not been fully interrupted, despite its roles in the expression of VGLUT2 in SNpr are likely mediated by regulation of thalamic afferents. Here, SLC17A6 is linked to Hand-foot syndrome.