SLC17A6 and Parkinson disease: High-frequency stimulation of the subthalamic nucleus (STN-HFS) can reverse the decrease in VGLUT2 expression, which provides evidence for the involvement of VGLUT2 in the regulation of basal ganglia circuitry, suggesting that VGLUT2 exert an important role in alleviating motor symptoms in PD (Favier et al., 2013).