The model was built using the mRMR FS method followed by the GLM classifier considering a total of 69 features that addressed sociodemographic profile, previous conditions, primary symptoms, performance status, tumor characterization (location, histology, TNM), genomic profile (EGFR and ALK expression), family cancer history, QoL, treatment regime, and RT dose (lung, esophagus, heart, GTV, and CTV). The gene discussed is ALK; the disease is cancer.