APOE and posterior cortical atrophy: Differential expression analysis on the dataset GSE32269 containing primary PCa and mCRPC tissue samples showed that the expression levels of RAD51, BLM, DTL, and APOE were significantly upregulated in mCRPC compared to those in primary PCa tissues (FDR < 0.05), while the expression of EXO1 and RFC2 were not significantly different (Figure 7h–m).