B2M and glycogen storage disease VI: The engineering strategy includes two TALEN-mediated knockouts to generate non-alloreactive, immune evasive CAR-modified T-cells: TRAC, to prevent Graft-versus-Host disease, and B2M to downregulate surface HLA-ABC expression which confers resistance to Host-versus-Graft rejection, thereby increasing their persistence in an allogeneic context (Figure 1C) (34).