Pro-inflammatory cytokines, including interferon-gamma (IFN-gamma), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-12 (IL-12), and interleukin-23 (IL-23), are crucial in the pathogenesis of MS (18, 19). This evidence concerns the gene IL37 and myeloid sarcoma.