IRF8 and allergic asthma: In order to understand functional differences between Xcr1+Irf8+Batf3+ cDC1 and Xcr1- Irf8+Batf3+ cDC1 clusters, we assessed differential gene expression in allergen-naïve control mice that had not been referred to the allergic asthma model or allergen tolerance model (Figure 2B; Supplementary FigureS2).