IRF8 and asthma: Cells of the Xcr1-Irf8+Fcgr1+ cDC2 cluster, which appeared only in allergen-treated animals of the asthma and tolerance model, showed high transcriptional activity in interferon-induced genes such as Ifit1, Ifrd1, Map3k14 and Infgr1 confirming the activated and pro-inflammatory character of this cell population (Figures 5A–C) as previously described (30, 39).