IRF8 and asthma: To further analyze the influx of pro-inflammatory Xcr1- Irf8+Batf3+ cDC1s in the lungs of mice with an allergic asthma-like disease (Figure 1A), we compared frequencies of Xcr1+ and Xcr1- cDC1s via flow cytometry in our experimental allergic asthma model and showed an increase in frequencies of pro-inflammatory Xcr1- CD172α- cDC1 in lungs of animals subjected to the asthma model (Figures 3C, D).