HES1 and Prader-Willi syndrome: A large number of upregulated genes with inflammation-related functions were observed in the CD16+ monocytes in PWS, including inflammatory activation-associated genes (e.g., IRF1, HES1, NFKBIA, ZFP36 and ATF3), and inflammation-related chemokine genes (e.g., CXCR4, CCL3, and CCL3L1).