These comorbidities were related to chronic inflammation and few studies demonstrated that PWS was associated with increased concentrations of circulating markers of inflammation, such as tumor necrosis factor (TNF) (12), interleukin-6 (IL-6) (13), interleukin-1β (IL-1β) (14), and C-reactive protein (CRP) (13, 15) compared to those with non-syndromic obesity. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.