Meanwhile, 9 cyclin-related genes (CCNC, CCND2, CCND3, CCNH, CCNI, CCNK, CCNL1, CCNL2, and CCNT1) were significantly upregulated in low-CR AD cells (Figure S1E), suggesting cell cycle activation was significant in low-CR group. Here, CCND2 is linked to Alzheimer disease.