Therefore, the complex interplay of the various signaling pathways implicated in the pathogenesis of MM (i.e., the RAS/RAF/MEK/ERK, the PI3K/AKT, the JAK/STAT, and the NF-κB pathways (71) with the KLF2 signaling network in MM cells needs to be further investigated. Here, AKT1 is linked to Miyoshi myopathy.