For NAFLD, some botanical drugs can target NLRP3 to exert anti-NAFLD effects, such as Antrodia Cinnamomea (Yen et al., 2020), Artemisia capillaris (Li B. et al., 2021), Juglans regia green husk (Fang et al., 2022), and extracts of Cannabis sativa (Jiang et al., 2021), which were found to reduce ROS, inhibit the NLRP3 in vitro and in vivo, and have a certain therapeutic effect on NAFLD. The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.