Some botanical drugs can target NLRP3 during AS and exert their effects, as found in vivo, S. plebeia can improve high glucose-mediated endothelial dysfunction by inhibiting PKCβII-related NLRP3 inflammasome activation and NF-κB signaling (Qin et al., 2016). The gene discussed is NLRP3; the disease is endothelial dysfunction.