It has also been shown that IL-15 not only promotes endurance and fuel supply, but also alleviate endoplasmic reticulum stress and improves cell survival, thus these findings support a role for IL-15 in the induction of exercise endurance and molecular adaptation in skeletal muscle (Quinn et al., 2013), as well as having the potential to treat cerebral ischemia (Nguyen et al., 2021; Zhu et al., 2022). The gene discussed is IL15; the disease is brain ischemia.