In addition, IFN-γ secreted by activated NK cells and CD8+ T cells stimulates cDC1 to secrete CXCL9 and CXCL10, which can recruit peripheral CXCR3+ NK and CD8+ T cells to tumor tissue, forming an immune positive feedback loop that maintains immune surveillance against tumors (Figure 3) (Bergamaschi et al., 2020). The gene discussed is CD8A; the disease is neoplasm.