For the T2DM model, IPGTT and IPITT demonstrated that compared with the control group, blood glucose levels in T2DM group were higher at all of the points tested at the age of 24 weeks, while levels in the PTPN2-overexpression group (T2DM + PTPN2) were lower than those in T2DM mice, indicating an improvement role of PTPN2 in IR and hyperglycaemia (Figures 5E, F). This evidence concerns the gene PTPN2 and type 2 diabetes mellitus.