SIRT1 and obesity due to melanocortin 4 receptor deficiency: Resveratrol is reported to exert its anti-obesity effect by the browning of WAT as well as by targeting several intracellular components such as sirtuin-1 (SIRT-1), adenosine monophosphate-activated protein kinase (AMPK), and the peroxisome proliferator-activated receptor coactivator-1 (PGC-1) (Price et al., 2012).