In a preclinical study, γ-Secretase inhibitor (GSI) is reported to reduce the Notch1, Th17 cell proportion and serum IL-17 in a diet-induced-obesity-ovalbumin (DIO-OVA) C57BL/6 mice model of asthma (Zeng et al., 2019). The gene discussed is IL17A; the disease is Obesity.