ALA has been demonstrated to drastically lower serum IgE concentration, attenuate Th2 cytokines, IL-4, IL-5, IL-13, and IL-18, and reduce NF-B activation by decreasing intracellular ROS levels in a mouse model of asthma with allergic airway inflammation (Bustamante et al., 1998). The gene discussed is IL4; the disease is asthma.