Tripterygium wilfordii, Hibiscus sabdariffa, Ilex paraguariensis, Coffea arabica, Caralluma fimbriata, Panax ginseng, plants from solanaceae family, and many others have all been shown to have positive effects on obesity through various mechanisms, such as appetite suppression, triglyceride reduction, metabolic rate increase, pancreatic lipase inhibition, and so on. Here, PNLIP is linked to obesity due to melanocortin 4 receptor deficiency.