As observed in the animal models, ALA exerted its anti-obesity effect by modulating oxidative stress, and inflammation and by increasing insulin sensitivity in the subcutaneous and visceral adipose tissue of high-fat diet rats (Dajnowicz-Brzezika et al., 2022; Sztolsztener et al., 2022). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.