HMOX1 and obesity due to melanocortin 4 receptor deficiency: BCP suppresses obesity-related AHR by its effects on macrophage polarization (inhibited by activation of AMPK, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, upregulation of adiponectin, glucagon-like peptide-1 (GLP-1), interferon-gamma (IFN-γ), superoxide dismutases (SOD), catalase, and downregulation of NF-κ-B, leptin, IL-4, TNF-α, and IL-1).