Before PSM, in the control group, the proportion of participants with tumor size ≥5 cm, multiple tumors, and AFP ≥400 ng/mL was higher than that in the Huaier group; moreover, the control-group patients were older and had higher MELD score, INR, PLT, and levels of ALT, AST, TBIL, γ-GGT, and Cr than those in the Huaier group (all p < 0.001). This evidence concerns the gene AFP and neoplasm.