Other studies have reported that Huaier granules regulate the proliferation, angiogenesis, and metastasis of HCC cells by the JNK, P38-MAPK, and YAP/CREB signaling pathways (Zhang et al., 2015; Zou et al., 2015; Niu et al., 2020). The gene discussed is CREB1; the disease is hepatocellular carcinoma.