Specifically, the presence of tumor-infiltrating lymphocytes (TILs), T cell (CD4+, CD8+, NK, γδ), macrophages, dendritic cells (DCs), B cells, mast cells, and neutrophils, as well as their localization, formation and density, can influence both the immune response and patient survival (Nossal, 1975; Fridman et al., 2012). This evidence concerns the gene CD4 and neoplasm.