CPT2, a key molecule in lipid metabolism, and the crosstalk between tumor metabolites including Malonyl-CoA, 1,1-Dimethylbiguanide, L-Palmitoylcarnitine, Estradiol, Propionyl-CoA, Palmityl-CoA, Palmitaldehyde, Coenzyme A, and Palmitic acid may offer new hope for tumor immunotherapy. This evidence concerns the gene CPT2 and neoplasm.