PPARα activated by clofibrate regulates cell cycle progression and apoptosis in pancreatic cancer cell lines, and the expression of PTPRZ1 and Wnt8a, two core components of the β-catenin pathway, is downregulated by clofibrate, increasing the sensitivity of pancreatic cancer cells to radiation therapy (Xue et al., 2018). Here, PPARA is linked to familial pancreatic carcinoma.