Decreases in its expression cause tumor cell sensitivity to death, its promoter region has a PPARγ response element, PPARγ can bind and inhibit its expression, and histopathological analysis of breast cancer biopsies obtained from patients with type II diabetes treated with ROSI has shown significant inhibition of NHE1 in tumor tissue (Kumar et al., 2009). The gene discussed is PPARG; the disease is type 2 diabetes mellitus.