The PI3K/AKT/mTOR and MAPK/ERK pathways are two important cell proliferation signaling pathways, among which PTEN is a natural inhibitor of the PI3K/AKT pathway, and ROSI activates PPARγ in HCC cell lines to bind to PTEN promoters and increase the expression of PTEN. The gene discussed is PTEN; the disease is hepatocellular carcinoma.