PPARA and malignant colon neoplasm: In addition, colon cancer grew more slowly in PPARα knockout mice than in wild-type mice, and TIDCs from PPARα knockout mice showed stronger anti-tumor effects than wild-type mice, suggesting that the PPARα signaling pathway is crucial in the immune function of TIDCs, and is involved in DC cell dysfunction caused by TME (Yin et al., 2020).