KLF2 and cancer: After siRNA silenced ODC1, the downregulation of ODC1 led to the upregulation of Krüppel-like factor 2 (KLF2), which in turn led to a decrease in PPARγ levels, inhibition of the expression of important regulators affecting glucose transport and lipid biogenesis in cancer cells, and a significant reduction in lipid droplet accumulation (Banerjee et al., 2003; Choi et al., 2016).