Furthermore, blocking PPARα in renal cell cancer cell lines under the synergistic effect of glycolytic inhibition significantly reduced the levels of the cell cycle-related proteins cyclin D1 and CDK4, and blocked the cell cycle in the G0/G1 phase, thereby reducing cell viability (Shah et al., 2007; Wang et al., 2011). The gene discussed is PPARA; the disease is renal cell adenocarcinoma.