Based on the ability of transmembrane transporters to transport nutrients from the extracellular compartment to the cytoplasm, K-Ras-mediated glucose transporter-1 (Glut1) expression leads to increased glucose uptake and cell survival under low glucose conditions, and PPARδ directly regulates Glut1 gene transcription, increasing glucose and amino acid uptake, activating mTOR signaling, resulting in tumor progression. The gene discussed is SLC2A1; the disease is neoplasm.