Another study showed that GW501560 increased VEGF expression in tumor cell lines in Apc (Min/+) mice, and VEGF directly promoted the survival of colorectal adenoma epithelial cells by activating PI3K-Akt signaling, which was manifested by a significant increase in the number and size of intestinal polyps (Gupta et al., 2004; Wang et al., 2006). This evidence concerns the gene VEGFA and colorectal adenoma.