2) Fenofibrate-mediated IGF-IR inhibition with PPARα-dependent metabolic induction and the resulting accumulation of ROS helps counteract glioma cell spread; likewise, fenofibrate-induced PPARα activation inhibits IGF-I-mediated growth and survival responses of medulloblastoma cell lines (Urbanska et al., 2008; Drukala et al., 2010). Here, PPARA is linked to central nervous system cancer.