TGFB1 and Familial prostate cancer: In prostate cancer cells, PPARβ/δ, as a key target of transforming growth factor β1 (TGF-β1), activates the cholesterol transporters ABCA1 and cave protein-1 (Cav1), leading TGF-β1 to induce tumor growth, migration, and invasion (Her et al., 2013).