Activation of PPARγ in macrophages leads to lipid retention and PGE2 secretion, favoring their polarization toward anti-inflammatory tumor-associated macrophages (TAM), reducing M1 macrophage biomarkers, and tilting towards the M2 phenotype, thereby altering macrophage fate and reducing the Stat3-mediated pro-inflammatory response (Penas et al., 2015; Souza-Moreira et al., 2019; Gionfriddo et al., 2020; Christofides et al., 2021). The gene discussed is PPARG; the disease is neoplasm.