NFKB1 and glioblastoma: 4) Fenofibrate not only alleviates glycolysis and lactic acid production in glioblastoma cells, but also damages the mitochondrial respiration of glioblastoma cells by inhibiting the transcriptional activity of NF-κB/RelA and destroying its association with hypoxia-inducible factor 1α (Han et al., 2015).