At the same time, the activation of PPARα also promotes the amp-activated protein kinase (AMPK) signaling pathway, which increases the oxidation of fatty acids, while effectively inhibiting the glycolysis of tumor cells, further reducing the production of ATP and resisting the occurrence of oral cancer (Chang and Huang, 2019; Grabacka et al., 2020). The gene discussed is PPARA; the disease is lip and oral cavity carcinoma.