PPARD and cancer: These three proteins work synergistically to increase the content of acetyl-CoA to promote glycolysis and fatty acid synthesis, while the PPARβ/δ agonist GW501516 improves their prometabolic efficiency and increases cancer cell aggressiveness in cancer model mice (Di-Poï et al., 2002; Pearce et al., 2010; Pollock et al., 2011).