PPARA and neoplasm: First, the synthetic PPARα agonists fenofibrate and Wy-14643 have been shown to inhibit vascular endothelial cell proliferation and tumor xenograft growth, whereas mice with PPARα deficiency showed a notable (p < 0.05) increase in neovascularization (Pozzi et al., 2007; Panigrahy et al., 2008).