In addition, colon cancer grew more slowly in PPARα knockout mice than in wild-type mice, and TIDCs from PPARα knockout mice showed stronger anti-tumor effects than wild-type mice, suggesting that the PPARα signaling pathway is crucial in the immune function of TIDCs, and is involved in DC cell dysfunction caused by TME (Yin et al., 2020). The gene discussed is PPARA; the disease is colonic neoplasm.