Nie et al. found that AS-IV (40 and 80 mg/kg/day) inhibited the degree of myocardial hypertrophy induced by AAC in rats and that this mechanism was related to the upregulation of the Nrf2/HO-1 signaling pathway (Nie et al., 2019a) (Figure 3). This evidence concerns the gene NFE2L2 and cardiac hypertrophy.