Zhang et al. induced diabetes in SD rats with streptozotocin (STZ) and found that AS-IV (10, 20, and 40 mg/kg/d) regulated energy metabolism by up-regulating PGC-1α and NRF, saving the abnormal energy metabolism caused by diabetes and thereby alleviating myocardial damage (Zhang et al., 2019b). This evidence concerns the gene PPARGC1A and diabetes mellitus.