PRKAB1 and cancer: AMPK isa crucial cellular energy sensor in eukaryotesthat maintains cellular energy homeostasis.61AMPK is activated when AMP/ATP is elevated, andit has one catalytic subunit (α) and two regulatory subunits(β and γ).62,63 Previous studies have shown that AMPK mediated quercetin-based induction of cancer cell apoptosis,alleviates mitochondrial dysfunction, and challenges the effects ofobesity.64−67 Growing evidence suggests that AMPK plays an importantrole in longevity.