The pathological changes of the ECM in the TM of POAG patients, as well as the increased contractility and stress fiber formation, are probably influenced by an increased concentration of TGF-β2 (Rodrigues et al., 1980; Babizhayev and Brodskaya, 1989; Tamm et al., 1996; Nakamura et al., 2002).Many of the TGF-β induced changes are mediated by CCN2/CTGF. The gene discussed is TGFB2; the disease is open-angle glaucoma.