TGFB1 and open-angle glaucoma: In the aqueous humor of patients with POAG, one of the best-described molecular change is an increased concentration of TGF-β2, whereas TGF-β1 was not altered (Ochiai and Ochiai, 2002), in contrast to patients with pseudoexfoliation glaucoma, who have increased concentration of TGF-β1 and no changes in TGF-β2 (Schlötzer-Schrehardt et al., 2001).