TGFB2 and open-angle glaucoma: In vitro studies demonstrated that increased concentrations of TGF-β2 could cause the pathologic alterations observed in the outflow tissues of POAG patients and in situ and in vivo administration of active TGF-β2 led to an increase in outflow resistance (Fuchshofer and Tamm, 2012; Patil et al., 2022).