Interestingly, we could observe enhanced levels of TGF-β1 and TGF-β2 in the transgenic βB1-CTGF1 mice accompanied by increased TGF-β signaling in the outflow tissues, which would make CCN2/CTGF of interest for pathological effects in both pseudoexfoliation glaucoma and POAG patients. This evidence concerns the gene CCN2 and open-angle glaucoma.