Recently, Wang et al. (2022) found enhanced O-GlCNAcylation at Ser555 of transcription factor ZEB1 in mesenchymal pancreatic cancer cells, which promoted FASN and FADS2 transcriptional activity and lipid peroxidation-dependent ferroptosis in cancer cells (Wang et al., 2022). The gene discussed is ZEB1; the disease is familial pancreatic carcinoma.