TFRC and hepatocellular carcinoma: Zhu et al. (2021) showed that O-GlcNAcylation increased RSL3-induced ferroptosis in HCC cells via YAP, and the OGA inhibitor PUGNAc-induced O-GlcNAcylation promoted YAP expression and nuclear localization (Zhu et al., 2021). YAP can directly bind to the TFRC promoter region and increase TFRC expression, promoting cellular iron uptake (Torii et al., 2016). These findings suggest that O-GlcNAcylation can affect ferroptosis by modulating TFRC and enhancing cellular iron uptake.