DDX53 and neoplasm: CT26-hN4 or Renca-hN4 tumor cells were implanted s.c. into BALB/c mice; 10 and 14 d later (17 and 21 d for Renca-hN4), R-421 was administered i.t. to the grown tumors in two doses of 1 × 108 PFU each (schedule depicted in Figure 7A).