This phenomenon was observed in tumor cells with high expression of SR-BI, such as human breast cancer MCF-7 cells and human hepatocellular carcinoma HepG2 cells, but not in those with low expression of SR-BI, such as human fibrosarcoma HT1080 cells, indicating a selective behavior because of the interaction between A and B described previously. The gene discussed is SCARB1; the disease is hepatocellular carcinoma.