In addition, Gsdme−/− mice and wild-type (WT) littermate controls were treated with 2,4,6-trinitrobenzenesulfonic acid (TNBS) to induce colitis, and the results showed that Gsdme−/− mice exhibit less severe intestinal inflammation than WT controls do (Tan and Chen, 2021b). Here, GSDME is linked to colitis.