Under glucose starvation, disulfidptosis is observed in cancer cells, where SLC7A11 expresses abnormally, cystine uptake increases, cystine reduces to cysteine, and the NADPH pool depletes, which results in excess accumulation of intracellular disulfide molecules and rapid cell death (Liu et al., 2020; Liu et al., 2023). Here, SLC7A11 is linked to cancer.