NME1 and cancer: ML showed that NME4 is a metastasis suppressor gene and localized in mitochondria, revealing a prominent role of altered NDPK-D in crucial features of cancer metastasis such as intercellular adhesion, migration, invasion, and EMT [20]; 2 weeks after tumor cells inoculation, intraperitoneal tumors of mice in the NM23-OE group were mainly in the mesentery, lower margin of the liver, and renal capsule, and there were no obvious ascites.