In histological subtype-stratified analyses, E354Q was also strongly associated with a higher risk of luminal A-like (OR:1.05, 95% CI:1.03–1.07, p = 6.02x10−7) and luminal B HER2 negative-like breast cancer (OR:1.06, 95% CI:1.02–1.10, p = 1.82x10−3)(Figure 1, Table S2). Here, ERBB2 is linked to breast carcinoma.