Here, we used a missense variant in GIPR, previously shown to result in impaired long-term GIPR signaling and decreased fasting and 2-h GIP concentrations, to predict the potential effect of such impaired GIPR signaling on the risk of 6 cancers influenced by hyperinsulinemia (overall and histotype-specific breast, colorectal, endometrial, lung, pancreatic, and renal cancers).28 The gene discussed is GIPR; the disease is hyperinsulinism.