These genes, including PSMB8, IRF8, IRF9, MX1, BST2, GBP2, IFITM2, ISG20, IFITM3, HLA-B, HLA-G, HLA-DRA, HLA-DPA1, ITGB2, ITGAM, HLA-DPB1, PTPRC, CCL2, HLA-DMA, and C1QB, were the most crucial in the PPI network and played an important role in the pathogenesis of DN. Here, IRF8 is linked to liver dysplastic nodule.