In our research, we found that FBXO43 expression was inversely correlated with immune infiltration score (including ImmuneScore, StromalScore and ESTIMATEScore) in HCC, but was positively related to the infiltration of macrophages (especially M2 macrophages), Tregs and neutrophils in HCC. The gene discussed is FBXO43; the disease is hepatocellular carcinoma.